-
Recent Research of Radiologic Diagnosis in Meniere’s Disease
-
Won Sang Lee, Young Joon Seo
-
Res Vestib Sci. 2010;9(4):121-127.
-
-
-
 Abstract
 PDF
- 동물 실험에서, 정맥 및 고실을 통한 Gd 결합체의 주입은 내이의 외림프액 공간의 조영 증강을 확인할 수 있었다. 와우축은 첨단를 통하지 않고 고실계와 전정계 사이에 외림프액을 소통하는 중요한 부위임이 밝혀졌으며, 이를 이용하여 Gd 결합체를 이용한 영상 기술은 더욱 발전할 것이다. 사람에서도 내림프수종을 시각화하는 데 성공하였으며, 고실을 통한 Gd 결합체 주입 후 다양한 MR 기술을 통하여 신호 대잡음 비가 높은 고 해상도의 영상을 얻을 수 있게 되었다.28 아직도 와우의 세부적인 구조를 시각화하는 데는 한계가 있지만, 저자는 내림프수종을 시각화하는 것은 메니에르병을 진단하는 데 필수적이고, 내림프액 공간의 영상과 증상간의 관계에 대한 앞으로의 연구가 내이의 질병들의 병인들을 밝히는 데 큰 역할을 할 것이라고 생각된다.
-
Visualization of endolymphatic hydrops using Magnetic Resonance Imaging after intratympanic Gd-DTPA administration in patients with Meniere’s disease
-
Young Joon Seo, Dae Bo Shim, Jinna Kim, Won Sang Lee
-
J Korean Bal Soc. 2008;7(2):167-173.
-
-
-
Abstract
PDF
- Background and Objectives: Endolymphatic hydrops are known as major causes of Meniere’s disease. MRI (Magnetic resonance imaging) with contrast tried recently makes it possible to visualize perilymphatic and endolymphatic space without invasive procedures. There are no tryouts in the interior of our country. We attempted MRI after injection of gadolinium-diethylen –triamine pentaacetic acid (Gd-DTPA) in normal adults and patients with Meniere’s disease to make sure 3D-FLAIR (fluid-attenuated inversion recovery) MRI parameters and to visualize endolymphatic spaces.
Materials and Methods: Five normal adults and Five patients with Meniere’s disease were included in this study. Twenty-four hours after Gd-DTPA intratympanic injection, we performed 3D-FLAIR and 3D-IR imaging at 3T. MRI region of interest signal intensity was used to determine the diffusion of Gd-DTPA into the perilymphatic fluid spaces over time.
Results: Five of five in normal group, using 3D-IR MRI after Gd injection, had enhanced imagings (perilymphatic spaces) of inner ears. Five of five in patients group, using 3D-IR after Gd injection, had enhanced perilymphatic spaces and non-enhanced endolymphatic hydrops.
Conclusions: Delayed contrast imaging of the inner ear with 3D-IR MRI after Gd-DTPA intratympanic injection revealed in vivo visualization of endolymphatic hydrops.
Key words: Endolymphatic hydrops, 3D-FLAIR MRI, Gd-DTPA, Intratympanic injection
|
KBS
